SCREEN-DR: Image Analysis and Machine Learning Platform for Innovation in Diabetic Retinopathy Screening

Aurelio Campilho  Asim Smailagic

"The SCREEN-DR project is an opportunity to generate synergy between more advanced Image Analysis and Machine Learning fields at exactly the right moment in the history of these fields.  This enables us to address three main challenges on this project: automatically evaluate image quality and removal of low quality images, automatically detect non-pathological cases, and automatically grade DR in several scales reflecting the disease severity. We will augment the contributions to the SCREEN DR project by further enhancing the learning machine. The project is the result of a unique blend of talent and experience from different disciplines such as biomedical and computer engineering, computer science, health administration and innovation fields." Aurélio Campilho and Asim Smailagic  

Portuguese PI
Aurélio Campilho
(INESC TEC; FEUP)
CMU PI
Asim Smailagic
(CMU; ICES)

Research teams: Carnegie Mellon University (CMU); Instituto de Engenharia de Sistemas e Computadores, Tecnologia e Ciência (INESC TEC); Universidade de Aveiro (UA)
Organizations: Administração Regional de Saúde do Norte (ARSN); BMD Software (BMD); First Solutions; Hospital de São João (CHSJ); University of Pittsburgh Medical Center, USA (UPMC)
Main Research Unit: Instituto de Engenharia de Sistemas e Computadores, Tecnologia e Ciência (INESC TEC)

Funding Reference: CMUP-ERI/TIC/0028/2014
Duration: 48 months 
Keywords: Medical image analysis; Computer-aided diagnosis; Collaborative PACS-Cloud; Diabetic retinopathy screening
 

Diabetic Retinopathy (DR) is a leading cause of blindness in the industrialized world that can be avoided with early treatment, demanding an earlier diagnosis in a stage where the treatment is still possible and effective. DR evolves silently without any visual symptoms, during the early stages of the disease. 

The Portuguese North Health Administration (ARSN) is implementing a mass screening for DR, with the goal of making eye exam of about 75% of identified diabetics, from an estimated diabetic population of 250.000, in the North of Portugal. 

SCREEN-DR is the platform to be developed in this project to face three main challenges. The first challenge is to automatically evaluate image quality, and consequent removal the low quality images from the workflow. The second is to automatically detect the non-pathological cases. If these two challenges are overcome, the ophthalmologists need to analyze only about 25% of the cases, which will be an important gain in terms of time-to-decision and efficacy. Additionally, the third challenge is to automatically grade DR in several scales of the disease severity. Each one of these challenges corresponds to an image module that will be remotely accessible by an image web service.  

Under this context, the vision of the consortium SCREEN-DR is to create a distributed and automatic screening platform for DR, based on the state-of-the-art Information and Communication Technologies (ICT), including advanced Picture Archiving and Communication Systems (PACS) management, Machine Learning and Image Analysis, enabling immediate response from health carers, allowing accurate follow-up strategies, and fostering technological innovation. 

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The Phase II of the Carnegie Mellon Portugal Program emphasizes advanced education and research that can lead to significant entrepreneurial impact. The activities of the program are for the most part configured in Entrepreneurial Research Initiatives (ERIs).

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